The main problem was time. I also had an other project that had to be finished and the render time of the smoke was too long. Yet, I rendered so that I could work on the other project in the meantime. I put 3 cores on rendering and used the fourth core for my work on my other project. Render time estimates kept increasing, so I rendered every tenth frame of the smoke. Luckely, I separated everything in render elements and I was able to composite everything back together. This way, my shot got rendered and I was able to make adjustments to the separate elements.